Glucose transporter isoform 4 is expressed in the syncytiotrophoblast of first trimester human placenta

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Glucose transporter isoform 4 is expressed in the syncytiotrophoblast of first trimester human placenta.

BACKGROUND Placental glucose transport mechanisms in early pregnancy are poorly understood. The aims of this study were to investigate the expression of glucose transporter (GLUT) isoforms 1, 3 and 4 in first trimester villous tissue, to assess the effects of insulin on glucose uptake and compare them with term. METHODS The expression of GLUT isoforms was investigated using immunohistochemist...

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The SNAT4 isoform of the system A amino acid transporter is expressed in human placenta

The system A amino acid transporter is encoded by three members of the Slc38 gene family giving rise to three subtypes: SNAT1, SNAT2, and SNAT4. SNAT2 is expressed ubiquitously in mammalian tissues, SNAT1 is predominantly expressed in heart, brain, and placenta while SNAT4 is reported to be expressed uniquely by the liver. In the placenta, system A has an essential role in the supply of neutral...

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SNAT4 isoform of system A amino acid transporter is expressed in human placenta.

The system A amino acid transporter is encoded by three members of the Slc38 gene family, giving rise to three subtypes: Na+-coupled neutral amino acid transporter (SNAT)1, SNAT2, and SNAT4. SNAT2 is expressed ubiquitously in mammalian tissues; SNAT1 is predominantly expressed in heart, brain, and placenta; and SNAT4 is reported to be expressed solely by the liver. In the placenta, system A has...

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The GLUT3 glucose transporter isoform is differentially expressed within human placental cell types.

The cellular localization of GLUT3 messenger ribonucleic acid (mRNA) and protein was examined in human term placenta using a combination of methodologies. In situ hybridization indicated that GLUT3 mRNA was present in the trophoblast cell layer and in vascular endothelium with a heterogeneous distribution pattern. GLUT3 protein migrating at an apparent molecular mass of 49 kDa was detected by i...

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ژورنال

عنوان ژورنال: Human Reproduction

سال: 2005

ISSN: 1460-2350,0268-1161

DOI: 10.1093/humrep/deh596